RÉFÉRENCES BIBLIOGRAPHIQUES

Altman J (1969) Autoradiographic et histological studies of postnatal neurogenesis. IV. Cell proliferation et migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol 137:433-457.

Altman J (1972a) Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells et of the molecular layer. J Comp Neurol 145:399-463.

Altman J (1972b) Postnatal development of the cerebellar cortex in the rat. 3. Maturation of the components of the granular layer. J Comp Neurol 145:465-513.

Altman J (1972c) Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer et the transitional molecular layer. J Comp Neurol 145:353-397.

Altman J, Das GD (1965) Autoradiographic et histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124:319-335.

Altman J, Bayer SA (1985a) Embryonic development of the rat cerebellum. I. Delineation of the cerebellar primordium et early cell movements. J Comp Neurol 231:1-26.

Altman J, Bayer SA (1985b) Embryonic development of the rat cerebellum. II. Translocation et regional distribution of the deep neurons. J Comp Neurol 231:27-41.

Altman J, Bayer SA (1985c) Embryonic development of the rat cerebellum. III. Regional differences in the time of origin, migration, et settling of Purkinje cells. J Comp Neurol 231:42-65.

Altman J, Bayer SA (1990a) Migration et distribution of two populations of hippocampal granule cell precursors during the perinatal et postnatal periods. J Comp Neurol 301:365-381.

Altman J, Bayer SA (1990b) Prolonged sojourn of developing pyramidal cells in the intermediate zone of the hippocampus et their settling in the stratum pyramidale. J Comp Neurol 301:343-364.

Altman J, Bayer SA (1990c) Mosaic organization of the hippocampal neuroepithelium et the multiple germinal sources of dentate granule cells. J Comp Neurol 301:325-342.

Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST et PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.

Annaert W, De Strooper B (1999) Presenilins: molecular switches between proteolysis et signal transduction. Trends Neurosci 22:439-443.

Annaert W, Cupers P, Saftig P, De Strooper B (2000) Presenilin function in APP processing. Ann N Y Acad Sci 920:158-164.

Arribas J, Coodly L, Vollmer P, Kishimoto TK, Rose-John S, Massague J (1996) Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J Biol Chem 271:11376-11382.

Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control et signal integration in development. Science 284:770-776.

Bang AG, Kintner C (2000) Rhomboid et Star facilitate presentation et processing of the Drosophila TGF-alpha homolog Spitz. Genes Dev 14:177-186.

Bassler BL (1999) How bacteria talk to each other: regulation of gene expression by quorum sensing. Curr Opin Microbiol 2:582-587.

Bayer SA (1980a) Development of the hippocampal region in the rat. II. Morphogenesis during embryonic et early postnatal life. J Comp Neurol 190:115-134.

Bayer SA (1980b) Development of the hippocampal region in the rat. I. Neurogenesis examined with 3H-thymidine autoradiography. J Comp Neurol 190:87-114.

Bayer SA (1983) 3H-thymidine-radiographic studies of neurogenesis in the rat olfactory bulb. Exp Brain Res 50:329-340.

Bayer SA, Altman J (1975) The effects of X-irradiation on the postnatally-forming granule cell populations in the olfactory bulb, hippocampus, et cerebellum of the rat. Exp Neurol 48:167-174.

Bayer SA, Yackel JW, Puri PS (1982) Neurons in the rat dentate gyrus granular layer substantially increase during juvenile et adult life. Science 216:890-892.

Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer JS, Basak A, Lazure C, Cromlish JA, Sisodia S, Checler F, Chretien M, Seidah NG (2001) Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) et its ectodomain shedding. The pro- et transmembrane/cytosolic domains affect its cellular activity et amyloid-beta production. J Biol Chem 276:10879-10887.

Bergmann A, Tugentman M, Shilo BZ, Steller H (2002) Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. Dev Cell 2:159-170.

Bier E (1998) Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays 20:189-194.

Bier E, Jan LY, Jan YN (1990) rhomboid, a gene required for dorsoventral axis establishment et peripheral nervous system development in Drosophila melanogaster. Genes Dev 4:190-203.

Black RA, White JM (1998) ADAMs: focus on the protease domain. Curr Opin Cell Biol 10:654-659.

Blaumueller CM, Artavanis-Tsakonas S (1997) Comparative aspects of Notch signaling in lower et higher eucaryotes. Perspect Dev Neurobiol 4:325-343.

Bogdan S, Klambt C (2001) Epidermal growth factor receptor signaling. Curr Biol 11:R292-295.

Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 et amyloid precursor proteins. Neuron 19:939-945.

Brenner S (1988) The molecular evolution of genes et proteins: a tale of two serines. Nature 334:528-530.

Brentrup D, Lerch H, Jackle H, Noll M (2000) Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid et is repressed by rhomboid-dependent Egfr signalling. Development 127:4729-4741.

Brou C, Logeat F, Gupta N, Bessia C, LeBail O, Doedens JR, Cumano A, Roux P, Black RA, Israel A (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell 5:207-216.

Brown JR, Doolittle WF (1997) Archaea et the procaryote-to-eucaryote transition. Microbiol Mol Biol Rev 61:456-502.

Brown MS, Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340.

Brown MS, Ye J, Rawson RB, Goldstein JL (2000) Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100:391-398.

Buonanno A, Fischbach GD (2001) Neuregulin et ErbB receptor signaling pathways in the nervous system. Curr Opin Neurobiol 11:287-296.

Burden S, Yarden Y (1997) Neuregulins et their receptors: a versatile signaling module in organogenesis et oncogenesis. Neuron 18:847-855.

Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA (1998) Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem 273:27765-27767.

Cai XD, Golde TE, Younkin SG (1993) Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259:514-516.

Cameron HA, Woolley CS, McEwen BS, Gould E (1993) Differentiation of newly born neurons et glia in the dentate gyrus of the adult rat. Neuroscience 56:337-344.

Cao X, Sudhof TC (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 et histone acetyltransferase Tip60. Science 293:115-120.

Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C (2000) Maturation et pro-peptide cleavage of beta-secretase. J Biol Chem 275:30849-30854.

Casci T, Freeman M (1999) Control of EGF receptor signalling: lessons from fruitflies. Cancer Metastasis Rev 18:181-201.

Chen H, Thiagalingam A, Chopra H, Borges MW, Feder JN, Nelkin BD, Baylin SB, Ball DW (1997) Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci U S A 94:5355-5360.

Chen MS, Bermingham-McDonogh O, Danehy FT, Jr., Nolan C, Scherer SS, Lucas J, Gwynne D, Marchionni MA (1994) Expression of multiple neuregulin transcripts in postnatal rat brains. J Comp Neurol 349:389-400.

Chien CT, Bartel PL, Sternglanz R, Fields S (1991) The two-hybrid system: a method to identify et clone genes for proteins that interact with a protein of interest. Proc Natl Acad Sci U S A 88:9578-9582.

Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360:672-674.

Cooper-Kuhn CM, Kuhn HG (2002) Is it all DNA repair? Methodological considerations for detecting neurogenesis in the adult brain. Brain Res Dev Brain Res 134:13-21.

Corfas G, Rosen KM, Aratake H, Krauss R, Fischbach GD (1995) Differential expression of ARIA isoforms in the rat brain. Neuron 14:103-115.

Corotto FS, Henegar JA, Maruniak JA (1993) Neurogenesis persists in the subependymal layer of the adult mouse brain. Neurosci Lett 149:111-114.

Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U, et al. (1985) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230:1132-1139.

Cryns V, Yuan J (1998) Proteases to die for. Genes Dev 12:1551-1570.

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391:387-390.

De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F (1997) Phosphorylation, subcellular localization, et membrane orientation of the Alzheimer's disease-associated presenilins. J Biol Chem 272:3590-3598.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398:518-522.

del Rio JA, Soriano E (1989) Immunocytochemical detection of 5'-bromodeoxyuridine incorporation in the central nervous system of the mouse. Brain Res Dev Brain Res 49:311-317.

Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS (1996) Protein topology of presenilin 1. Neuron 17:1023-1030.

Dominguez M, Wasserman JD, Freeman M (1998) Multiple functions of the EGF receptor in Drosophila eye development. Curr Biol 8:1039-1048.

Ebinu JO, Yankner BA (2002) A RIP tide in neuronal signal transduction. Neuron 34:499-502.

Egan SE, St-Pierre B, Leow CC (1998) Notch receptors, partners et regulators: from conserved domains to powerful functions. Curr Top Microbiol Immunol 228:273-324.

Elenius K, Corfas G, Paul S, Choi CJ, Rio C, Plowman GD, Klagsbrun M (1997) A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution et differential processing in response to phorbol ester. J Biol Chem 272:26761-26768.

Esser K, Tursun B, Ingenhoven M, Michaelis G, Pratje E (2002) A novel two-step mechanism for removal of a mitochondrial signal sequence involves the mAAA complex et the putative rhomboid protease Pcp1. J Mol Biol 323:835-843.

Estojak J, Brent R, Golemis EA (1995) Correlation of two-hybrid affinity data with in vitro measurements. Mol Cell Biol 15:5820-5829.

Felsenstein J (1996) Inferring phylogenies from protein sequences by parsimony, distance, et likelihood methods. Methods Enzymol 266:418-427.

Fields S, Song O (1989) A novel genetic system to detect protein-protein interactions. Nature 340:245-246.

Fitch WM, Margoliash E (1967) Construction of phylogenetic trees. Science 155:279-284.

Fortini ME (2001) Notch et presenilin: a proteolytic mechanism emerges. Curr Opin Cell Biol 13:627-634.

Fortini ME (2002) Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol 3:673-684.

Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D (2002) aph-1 et pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, et presenilin protein accumulation. Dev Cell 3:85-97.

Galperin MY, Koonin EV (1999) Functional genomics et enzyme evolution. Homologous et analogous enzymes encoded in microbial genomes. Genetica 106:159-170.

Garratt AN, Britsch S, Birchmeier C (2000) Neuregulin, a factor with many functions in the life of a schwann cell. Bioessays 22:987-996.

Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, Lemke G (1995) Aberrant neural et cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378:390-394.

Ghiglione C, Bach EA, Paraiso Y, Carraway KL, 3rd, Noselli S, Perrimon N (2002) Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development 129:175-186.

Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425-430.

Golembo M, Raz E, Shilo BZ (1996) The Drosophila embryonic midline is the site of Spitz processing, et induces activation of the EGF receptor in the ventral ectoderm. Development 122:3363-3370.

Golemis E, A., Gyuris, J., Brent, R. (1996) Using yeast two-hybrid systems to identify interacting proteins. In: Analysis of protein interactions, p chap. 20.20 & 20.21: J. Willey & Sons Inc.

Goutte C, Tsunozaki M, Hale VA, Priess JR (2002) APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A 99:775-779.

Guichard A, Biehs B, Sturtevant MA, Wickline L, Chacko J, Howard K, Bier E (1999) rhomboid et Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development 126:2663-2676.

Hajos F, Kalman M (1989) Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain. II. Mesencephalon, rhombencephalon et spinal cord. Exp Brain Res 78:164-173.

Handler M, Yang X, Shen J (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127:2593-2606.

Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M (2000) Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. J Biol Chem 275:21099-21106.

Hatten ME (1999) Central nervous system neuronal migration. Annu Rev Neurosci 22:511-539.

Hidalgo A, Kinrade EF, Georgiou M (2001) The Drosophila neuregulin vein maintains glial survival during axon guidance in the CNS. Dev Cell 1:679-690.

Ho KS, Scott MP (2002) Sonic hedgehog in the nervous system: functions, modifications et mechanisms. Curr Opin Neurobiol 12:57-63.

Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW, Yansura D, Abadi N, Raab H, Lewis GD, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science 256:1205-1210.

Hua X, Sakai J, Ho YK, Goldstein JL, Brown MS (1995) Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. J Biol Chem 270:29422-29427.

Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (1993) SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci U S A 90:11603-11607.

Huse JT, Pijak DS, Leslie GJ, Lee VM, Doms RW (2000) Maturation et endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase. J Biol Chem 275:33729-33737.

Huse JT, Bryant D, Yang Y, Pijak DS, D'Souza I, Lah JJ, Lee VM, Doms RW, Cook DG (2003) Endoproteolysis of beta-secretase (BACE) within its catalytic domain: A potential mechanism for regulation. J Biol Chem.

Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 14:419-427.

Huttner WB, Schiebler W, Greengard P, De Camilli P (1983) Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation. J Cell Biol 96:1374-1388.

Hynes M, Porter JA, Chiang C, Chang D, Tessier-Lavigne M, Beachy PA, Rosenthal A (1995) Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15:35-44.

Ino H, Chiba T (2000) Expression of proliferating cell nuclear antigen (PCNA) in the adult et developing mouse nervous system. Brain Res Mol Brain Res 78:163-174.

Iso T, Kedes L, Hamamori Y (2003) HES et HERP families: Multiple effectors of the notch signaling pathway. J Cell Physiol 194:237-255.

Jain R, Rivera MC, Lake JA (1999) Horizontal gene transfer among genomes: the complexity hypothesis. Proc Natl Acad Sci U S A 96:3801-3806.

Jaszai J, Brand M (2002) Cloning et expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid. Mech Dev 113:73-77.

Kaplan MS, Hinds JW (1977) Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197:1092-1094.

Kaplan MS, Bell DH (1983) Neuronal proliferation in the 9-month-old rodent-radioautographic study of granule cells in the hippocampus. Exp Brain Res 52:1-5.

Kempermann G, Kuhn HG, Gage FH (1997) Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A 94:10409-10414.

Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ (2000) The transmembrane aspartates in presenilin 1 et 2 are obligatory for gamma-secretase activity et amyloid beta-protein generation. J Biol Chem 275:3173-3178.

King RW, Deshaies RJ, Peters JM, Kirschner MW (1996) How proteolysis drives the cell cycle. Science 274:1652-1659.

Kirschenbaum F, Hsu SC, Cordell B, McCarthy JV (2001) Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels. J Biol Chem 276:30701-30707.

Kishi K (1987) Golgi studies on the development of granule cells of the rat olfactory bulb with reference to migration in the subependymal layer. J Comp Neurol 258:112-124.

Klambt C (2000) EGF receptor signalling: the importance of presentation. Curr Biol 10:R388-391.

Koonin EV, Galperin, M.Y. (2002) Sequence-Evolution-Function, computational approaches in comparative genomics. N.Y.: Kluwer Acad. Publ.

Kopan R, Goate A (2000) A common enzyme connects notch signaling et Alzheimer's disease. Genes Dev 14:2799-2806.

Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA (1989) Isolation et characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A 86:9193-9197.

Kuhn HG, Dickinson-Anson H, Gage FH (1996) Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 16:2027-2033.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C (2002) Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain et the secretion of an Abeta-like peptide. J Biol Chem 277:44754-44759.

Lang BF, Gray MW, Burger G (1999) Mitochondrial genome evolution et the origin of eucaryotes. Annu Rev Genet 33:351-397.

Lau KF, Howlett DR, Kesavapany S, Standen CL, Dingwall C, McLoughlin DM, Miller CC (2002) Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability. Mol Cell Neurosci 20:13-20.

Lee HJ, Jung KM, Huang YZ, Bennett LB, Lee JS, Mei L, Kim TW (2002a) Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem 277:6318-6323.

Lee JR, Urban S, Garvey CF, Freeman M (2001) Regulated intracellular ligand transport et proteolysis control EGF signal activation in Drosophila. Cell 107:161-171.

Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ (2002b) IRE1-mediated unconventional mRNA splicing et S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev 16:452-466.

Lee KF, Simon H, Chen H, Bates B, Hung MC, Hauser C (1995) Requirement for neuregulin receptor erbB2 in neural et cardiac development. Nature 378:394-398.

Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS (1996) Expression of presenilin 1 et 2 (PS1 et PS2) in human et murine tissues. J Neurosci 16:7513-7525.

Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-354.

Lewis AP, Thomas PJ (1999) A novel clan of zinc metallopeptidases with possible intramembrane cleavage properties. Protein Sci 8:439-442.

Li X, Greenwald I (1996) Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17:1015-1021.

Li X, Greenwald I (1998) Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans et human presenilins. Proc Natl Acad Sci U S A 95:7109-7114.

Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ (2000) Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci U S A 97:6138-6143.

Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC (2001) Nuclear localization of EGF receptor et its potential new role as a transcription factor. Nat Cell Biol 3:802-808.

Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A 97:1456-1460.

Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israel A (1998) The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A 95:8108-8112.

Lois C, Alvarez-Buylla A (1993) Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons et glia. Proc Natl Acad Sci U S A 90:2074-2077.

Lundkvist J, Lendahl U (2001) Notch et the birth of glial cells. Trends Neurosci 24:492-494.

Massague J, Pandiella A (1993) Membrane-anchored growth factors. Annu Rev Biochem 62:515-541.

Memberg SP, Hall AK (1995) Dividing neuron precursors express neuron-specific tubulin. J Neurobiol 27:26-43.

Menezes JR, Luskin MB (1994) Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon. J Neurosci 14:5399-5416.

Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R (1995) Epithelial immaturity et multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337-341.

Montero JC, Yuste L, Diaz-Rodriguez E, Esparis-Ogando A, Pandiella A (2000) Differential shedding of transmembrane neuregulin isoforms by the tumor necrosis factor-alpha-converting enzyme. Mol Cell Neurosci 16:631-648.

Moreno-Flores MT, Medina M, Wandosell F (1999) Expression of presenilin 1 in nervous system during rat development. J Comp Neurol 410:556-570.

Morrison SJ (2001) Neuronal potential et lineage determination by neural stem cells. Curr Opin Cell Biol 13:666-672.

Morrissey TK, Levi AD, Nuijens A, Sliwkowski MX, Bunge RP (1995) Axon-induced mitogenesis of human Schwann cells involves heregulin et p185erbB2. Proc Natl Acad Sci U S A 92:1431-1435.

Mullen RJ, Buck CR, Smith AM (1992) NeuN, a neuronal specific nuclear protein in vertebrates. Development 116:201-211.

Mushegian AR, Koonin EV (1996) Sequence analysis of eucaryotic developmental proteins: ancient et novel domains. Genetics 144:817-828.

Nagy A, Baker RR, Morris SJ, Whittaker VP (1976) The preparation et characterization of synaptic vesicles of high purity. Brain Res 109:285-309.

Ni CY, Murphy MP, Golde TE, Carpenter G (2001) gamma -Secretase cleavage et nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294:2179-2181.

Niwa M, Sidrauski C, Kaufman RJ, Walter P (1999) A role for presenilin-1 in nuclear accumulation of Ire1 fragments et induction of the mammalian unfolded protein response. Cell 99:691-702.

Ohsako S, Hyer J, Panganiban G, Oliver I, Caudy M (1994) Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes Dev 8:2743-2755.

Ohtsuka T, Ishibashi M, Gradwohl G, Nakanishi S, Guillemot F, Kageyama R (1999) Hes1 et Hes5 as notch effectors in mammalian neuronal differentiation. Embo J 18:2196-2207.

Olayioye MA, Neve RM, Lane HA, Hynes NE (2000) The ErbB signaling network: receptor heterodimerization in development et cancer. Embo J 19:3159-3167.

Pascall JC, Brown KD (1998) Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid. FEBS Lett 429:337-340.

Passer B, Pellegrini L, Russo C, Siegel RM, Lenardo MJ, Schettini G, Bachmann M, Tabaton M, D'Adamio L (2000) Generation of an Apoptotic Intracellular Peptide by gamma-Secretase Cleavage of Alzheimer's Amyloid beta Protein Precursor. J Alzheimers Dis 2:289-301.

Pellegrini L, Passer BJ, Canelles M, Lefterov I, Ganjei JK, Fowkles BJ, Koonin E, V., D'Adamio L (2001) PAMP et PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 et -2. Journal of Alzheimer's disease 3:181-190.

Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M (1993) Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci U S A 90:1746-1750.

Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ (1997) Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 et Ala299 et occur as stable N- et C-terminal fragments in normal et Alzheimer brain tissue. Neurobiol Dis 3:325-337.

Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE (2002) Identification of a novel family of presenilin homologues. Hum Mol Genet 11:1037-1044.

Porter JA, Young KE, Beachy PA (1996a) Cholesterol modification of hedgehog signaling proteins in animal development. Science 274:255-259.

Porter JA, Ekker SC, Park WJ, von Kessler DP, Young KE, Chen CH, Ma Y, Woods AS, Cotter RJ, Koonin EV, Beachy PA (1996b) Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86:21-34.

Rather PN, Parojcic MM, Paradise MR (1997) An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii. Antimicrob Agents Chemother 41:1749-1754.

Rather PN, Ding X, Baca-DeLancey RR, Siddiqui S (1999) Providencia stuartii genes activated by cell-to-cell signaling et identification of a gene required for production or activity of an extracellular factor. J Bacteriol 181:7185-7191.

Ratovitski T, Slunt HH, Thinakaran G, Price DL, Sisodia SS, Borchelt DR (1997) Endoproteolytic processing et stabilization of wild-type et mutant presenilin. J Biol Chem 272:24536-24541.

Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL (1997) Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol Cell 1:47-57.

Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM (1999) Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem 274:36801-36807.

Reich A, Shilo BZ (2002) Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage. Embo J 21:4287-4296.

Riethmacher D, Brinkmann V, Birchmeier C (1995) A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc Natl Acad Sci U S A 92:855-859.

Rio C, Buxbaum JD, Peschon JJ, Corfas G (2000) Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4. J Biol Chem 275:10379-10387.

Rio C, Rieff HI, Qi P, Khurana TS, Corfas G (1997) Neuregulin et erbB receptors play a critical role in neuronal migration. Neuron 19:39-50.

Roelink H, Porter JA, Chiang C, Tanabe Y, Chang DT, Beachy PA, Jessell TM (1995) Floor plate et motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell 81:445-455.

Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T, et al. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376:775-778.

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L (2002) The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb et inhibits Notch signaling. Proc Natl Acad Sci U S A 99:7102-7107.

Rudner DZ, Fawcett P, Losick R (1999) A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. Proc Natl Acad Sci U S A 96:14765-14770.

Rutledge BJ, Zhang K, Bier E, Jan YN, Perrimon N (1992) The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation et neurogenesis. Genes Dev 6:1503-1517.

Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL (1996) Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85:1037-1046.

Salzberg SL, White O, Peterson J, Eisen JA (2001) Microbial genes in the human genome: lateral transfer or gene loss? Science 292:1903-1906.

Scheffler B, Horn M, Blumcke I, Laywell ED, Coomes D, Kukekov VG, Steindler DA (1999) Marrow-mindedness: a perspective on neuropoiesis. Trends Neurosci 22:348-357.

Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211-225.

Schnepp B, Grumbling G, Donaldson T, Simcox A (1996) Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev 10:2302-2313.

Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-386.

Schweitzer R, Shilo BZ (1997) A thousand et one roles for the Drosophila EGF receptor. Trends Genet 13:191-196.

Schweitzer R, Shaharabany M, Seger R, Shilo BZ (1995) Secreted Spitz triggers the DER signaling pathway et is a limiting component in embryonic ventral ectoderm determination. Genes Dev 9:1518-1529.

Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S (1997) Evidence for phosphorylation et oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A 94:5090-5094.

Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:A23-31.

Selkoe DJ (2001) Alzheimer's disease: genes, proteins, et therapy. Physiol Rev 81:741-766.

Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S (1997) Skeletal et CNS defects in Presenilin-1-deficient mice. Cell 89:629-639.

Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.

Shinoda J, Nakao J, Iizuka Y, Toba Y, Yazaki T, Kawase T, Uyemura K (1997) Multiple isoforms of neuregulin are expressed in developing rat dorsal root ganglia. J Neurosci Res 50:673-683.

Shmueli A, Cohen-Gazala O, Neuman-Silberberg FS (2002) Gurken, a TGF-alpha-like protein involved in axis determination in Drosophila, directly binds to the EGF-receptor homolog Egfr. Biochem Biophys Res Commun 291:732-737.

Shoelson SE (1997) SH2 et PTB domain interactions in tyrosine kinase signal transduction. Curr Opin Chem Biol 1:227-234.

Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, John V, et al. (1999) Purification et cloning of amyloid precursor protein beta-secretase from human brain. Nature 402:537-540.

Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM (2000) Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J Biol Chem 275:2568-2575.

Small DM, Shipley GG (1974) Physical-chemical basis of lipid deposition in atherosclerosis. Science 185:222-229.

Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA (1999) Proteolytic release et nuclear translocation of Notch-1 are induced by presenilin-1 et impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A 96:6959-6963.

Steiner H, Haass C (2000) Intramembrane proteolysis by presenilins. Nat Rev Mol Cell Biol 1:217-224.

Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C (2000) Glycine 384 is required for presenilin-1 function et is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol 2:848-851.

Struhl G, Greenwald I (1999) Presenilin is required for activity et nuclear access of Notch in Drosophila. Nature 398:522-525.

Sturtevant MA, Roark M, Bier E (1993) The Drosophila rhomboid gene mediates the localized formation of wing veins et interacts genetically with components of the EGF-R signaling pathway. Genes Dev 7:961-973.

Tatusov RL, Natale DA, Garkavtsev IV, Tatusova TA, Shankavaram UT, Rao BS, Kiryutin B, Galperin MY, Fedorova ND, Koonin EV (2001) The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res 29:22-28.

Taupin P, Gage FH (2002) Adult neurogenesis et neural stem cells of the central nervous system in mammals. J Neurosci Res 69:745-749.

Thewke D, Kramer M, Sinensky MS (2000) Transcriptional homeostatic control of membrane lipid composition. Biochem Biophys Res Commun 273:1-4.

Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1996) Endoproteolysis of presenilin 1 et accumulation of processed derivatives in vivo. Neuron 17:181-190.

Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties et weight matrix choice. Nucleic Acids Res 22:4673-4680.

Tsruya R, Schlesinger A, Reich A, Gabay L, Sapir A, Shilo BZ (2002) Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Genes Dev 16:222-234.

Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, et al. (1984) Human epidermal growth factor receptor cDNA sequence et aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309:418-425.

Urban S, Freeman M (2002) Intramembrane proteolysis controls diverse signalling pathways throughout evolution. Curr Opin Genet Dev 12:512-518.

Urban S, Lee JR, Freeman M (2001) Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107:173-182.

Urban S, Schlieper D, Freeman M (2002a) Conservation of intramembrane proteolytic activity et substrate specificity in procaryotic et eucaryotic rhomboids. Curr Biol 12:1507.

Urban S, Lee JR, Freeman M (2002b) A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. Embo J 21:4277-4286.

van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH (2002) Functional neurogenesis in the adult hippocampus. Nature 415:1030-1034.

Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741.

Vecchi M, Carpenter G (1997) Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism. J Cell Biol 139:995-1003.

Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C (2001) Phosphorylation regulates intracellular trafficking of beta-secretase. J Biol Chem 276:14634-14641.

Wang X, Sato R, Brown MS, Hua X, Goldstein JL (1994) SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53-62.

Wasserman JD, Urban S, Freeman M (2000) A family of rhomboid-like genes: Drosophila rhomboid-1 et roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev 14:1651-1663.

Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (2002) Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296:2215-2218.

Weinmaster G (1997) The ins et outs of notch signaling. Mol Cell Neurosci 9:91-102.

Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC, Reynolds BA (1996) Multipotent CNS stem cells are present in the adult mammalian spinal cord et ventricular neuroaxis. J Neurosci 16:7599-7609.

Wen PH, Friedrich VL, Jr., Shioi J, Robakis NK, Elder GA (2002) Presenilin-1 is expressed in neural progenitor cells in the hippocampus of adult mice. Neurosci Lett 318:53-56.

Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43:567-581.

Wolfe MS, Selkoe DJ (2002) Biochemistry. Intramembrane proteases--mixing oil et water. Science 296:2156-2157.

Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ (1999a) Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry 38:11223-11230.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999b) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis et gamma-secretase activity. Nature 398:513-517.

Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, Wada M, Honjo M, Takahashi M, Takahashi T, Hirai H, Tsushima T, Akanuma Y, Fujita T, Komuro I, Yazaki Y, Kadowaki T (1998) Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation et gene expression. Endocr J 45 Suppl:S27-31.

Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402:533-537.

Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS, Goldstein JL (2000) ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell 6:1355-1364.

Ye Y, Fortini ME (2000) Proteolysis et developmental signal transduction. Semin Cell Dev Biol 11:211-221.

Ye Y, Lukinova N, Fortini ME (1999) Neurogenic phenotypes et altered Notch processing in Drosophila Presenilin mutants. Nature 398:525-529.

Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS (1993) SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75:187-197.

Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction et betaAPP processing. Nature 407:48-54.

Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ (1997) Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds et activates ErbB4. Proc Natl Acad Sci U S A 94:9562-9567.

Zhou W, Carpenter G (2000) Heregulin-dependent trafficking et cleavage of ErbB-4. J Biol Chem 275:34737-34743.