1. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes . 1988;37:1595-607.

2. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama . 2001;285:2486-97.

3. Poirier P, Despres JP. [Obesity and cardiovascular disease]. Med Sci (Paris) . 2003;19:943-9.

4. (WHO) WHO. Definition, Diagnosis and Classification of diabetes mellitus and its complications. Report of a WHO consultation, Part 1: Diagnosis and Classification of Diabetes Mellitus. 1999.

5. Einhorn D, Reaven GM, Cobin RH, Ford E, Ganda OP, Handelsman Y, Hellman R, Jellinger PS, Kendall D, Krauss RM, Neufeld ND, Petak SM, Rodbard HW, Seibel JA, Smith DA, Wilson PW. American College of Endocrinology position statement on the insulin resistance syndrome. Endocr Pract . 2003;9:237-52.

6. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The continuing epidemic of obesity in the United States. Jama . 2000;284:1650-1.

7. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Jama . 2002;287:356-9.

8. Grundy SM, Brewer HB, Jr., Cleeman JI, Smith SC, Jr., Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation . 2004;109:433-8.

9. Pouliot MC, Despres JP, Nadeau A, Moorjani S, Prud'Homme D, Lupien PJ, Tremblay A, Bouchard C. Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes . 1992;41:826-34.

10. Despres JP. Health consequences of visceral obesity. Ann Med . 2001;33:534-41.

11. Jazet IM, Pijl H, Meinders AE. Adipose tissue as an endocrine organ: impact on insulin resistance. Neth J Med . 2003;61:194-212.

12. Despres JP, Lemieux I, Prud'homme D. Treatment of obesity: need to focus on high risk abdominally obese patients. Bmj . 2001;322:716-20.

13. Abbasi F, Brown BW, Jr., Lamendola C, McLaughlin T, Reaven GM. Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol . 2002;40:937-43.

14. Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest . 1997;100:1166-73.

15. Reaven GM. The insulin resistance syndrome. Curr Atheroscler Rep . 2003;5:364-71.

16. McLaughlin T, Abbasi F, Lamendola C, Liang L, Reaven G, Schaaf P, Reaven P. Differentiation between obesity and insulin resistance in the association with C-reactive protein. Circulation . 2002;106:2908-12.

17. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes . 1992;41:715-22.

18. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. Jama . 2002;288:2709-16.

19. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care . 2001;24:683-9.

20. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation . 1998;97:1837-47.

21. Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation . 2002;105:310-5.

22. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet . 1994;344:1383-9.

23. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet . 2002;360:7-22.

24. Genest J, Jr., McNamara JR, Ordovas JM, Jenner JL, Silberman SR, Anderson KM, Wilson PW, Salem DN, Schaefer EJ. Lipoprotein cholesterol, apolipoprotein A-I and B and lipoprotein (a) abnormalities in men with premature coronary artery disease. J Am Coll Cardiol . 1992;19:792-802.

25. Ginsburg GS, Safran C, Pasternak RC. Frequency of low serum high-density lipoprotein cholesterol levels in hospitalized patients with "desirable" total cholesterol levels. Am J Cardiol . 1991;68:187-92.

26. Superko HR. Beyond LDL cholesterol reduction. Circulation . 1996;94:2351-4.

27. Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, Despres JP. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation . 1997;95:69-75.

28. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med . 1996;334:952-7.

29. Lamarche B, Moorjani S, Lupien PJ, Cantin B, Bernard PM, Dagenais GR, Despres JP. Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the Quebec cardiovascular study. Circulation . 1996;94:273-8.

30. Lamarche B, Tchernof A, Mauriege P, Cantin B, Dagenais GR, Lupien PJ, Despres JP. Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. Jama . 1998;279:1955-61.

31. Lemieux I, Pascot A, Couillard C, Lamarche B, Tchernof A, Almeras N, Bergeron J, Gaudet D, Tremblay G, Prud'homme D, Nadeau A, Despres JP. Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation . 2000;102:179-84.

32. Rao DC. Genetic dissection of complex traits: an overview. Adv Genet . 2001;42:13-34.

33. Harrap SB. Where are all the blood-pressure genes? Lancet . 2003;361:2149-51.

34. Sing CF, Stengard JH, Kardia SL. Genes, environment, and cardiovascular disease. Arterioscler Thromb Vasc Biol . 2003;23:1190-6.

35. Bouchard C, Malina RM, Pérusse L. Genetics of fitness and physical performance . Champaign, IL: Human Kinetics; 1997.

36. Rice TK, Borecki IB. Familial resemblance and heritability. Adv Genet . 2001;42:35-44.

37. Casci T. Free associations. Nat Rev Genet . 2002;3:904.

38. Almasy L, MacCluer JW. Association studies of vascular phenotypes: how and why? Arterioscler Thromb Vasc Biol . 2002;22:1055-7.

39. Lander ES, Schork NJ. Genetic dissection of complex traits. Science . 1994;265:2037-48.

40. Ardlie KG, Kruglyak L, Seielstad M. Patterns of linkage disequilibrium in the human genome. Nat Rev Genet . 2002;3:299-309.

41. The International HapMap Project. Nature . 2003;426:789-96.

42. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. A comprehensive review of genetic association studies. Genet Med . 2002;4:45-61.

43. Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet . 1999;65:220-8.

44. Devlin B, Roeder K. Genomic control for association studies. Biometrics . 1999;55:997-1004.

45. Reich DE, Goldstein DB. Detecting association in a case-control study while correcting for population stratification. Genet Epidemiol . 2001;20:4-16.

46. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet . 1993;52:506-16.

47. Schulze TG, McMahon FJ. Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am J Med Genet . 2002;114:1-11.

48. Hegele RA. SNP judgments and freedom of association. Arterioscler Thromb Vasc Biol . 2002;22:1058-61.

49. Hirschhorn JN, Altshuler D. Once and again-issues surrounding replication in genetic association studies. J Clin Endocrinol Metab . 2002;87:4438-41.

50. Tabor HK, Risch NJ, Myers RM. Opinion: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet . 2002;3:391-7.

51. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet . 2003;33:177-82.

52. Goldstein DB, Ahmadi KR, Weale ME, Wood NW. Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. Trends Genet . 2003;19:615-22.

53. Freely associating. Nat Genet . 1999;22:1-2.

54. Heistad DD. Genetic association studies. Arterioscler Thromb Vasc Biol . 2002;22:1054.

55. Venter JC, et al. The sequence of the human genome. Science . 2001;291:1304-51.

56. Kruglyak L, Nickerson DA. Variation is the spice of life. Nat Genet . 2001;27:234-6.

57. Lander ES, et al. Initial sequencing and analysis of the human genome. Nature . 2001;409:860-921.

58. Morton NE. Sequential tests for the detection of linkage. Am J Hum Genet . 1955;7:277-318.

59. Rice JP, Saccone NL, Corbett J. The lod score method. Adv Genet . 2001;42:99-113.

60. Borecki IB, Suarez BK. Linkage and association: basic concepts. Adv Genet . 2001;42:45-66.

61. Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet . 1972;2:3-19.

62. Amos CI. Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet . 1994;54:535-43.

63. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet . 1998;62:1198-211.

64. Blangero J, Williams JT, Almasy L. Variance component methods for detecting complex trait loci. Adv Genet . 2001;42:151-81.

65. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science . 1996;273:1516-7.

66. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet . 1995;11:241-7.

67. Glazier AM, Nadeau JH, Aitman TJ. Finding genes that underlie complex traits. Science . 2002;298:2345-9.

68. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS. Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet . 1999;65:876-84.

69. Curtsinger JW. Peeking under QTL peaks. Nat Genet . 2003;34:358-9.

70. Risch NJ. Searching for genetic determinants in the new millennium. Nature . 2000;405:847-56.

71. Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet . 2003;33 Suppl:228-37.

72. Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science . 1997;278:1580-1.

73. Jeffreys AJ, Kauppi L, Neumann R. Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet . 2001;29:217-22.

74. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D. The structure of haplotype blocks in the human genome. Science . 2002;296:2225-9.

75. Abecasis GR, Noguchi E, Heinzmann A, Traherne JA, Bhattacharyya S, Leaves NI, Anderson GG, Zhang Y, Lench NJ, Carey A, Cardon LR, Moffatt MF, Cookson WO. Extent and distribution of linkage disequilibrium in three genomic regions. Am J Hum Genet . 2001;68:191-197.

76. Dawson E, Abecasis GR, Bumpstead S, Chen Y, Hunt S, Beare DM, Pabial J, Dibling T, Tinsley E, Kirby S, Carter D, Papaspyridonos M, Livingstone S, Ganske R, Lohmussaar E, Zernant J, Tonisson N, Remm M, Magi R, Puurand T, Vilo J, Kurg A, Rice K, Deloukas P, Mott R, Metspalu A, Bentley DR, Cardon LR, Dunham I. A first-generation linkage disequilibrium map of human chromosome 22. Nature . 2002;418:544-8.

77. Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES. Linkage disequilibrium in the human genome. Nature . 2001;411:199-204.

78. Bouchard C. Genetics and the metabolic syndrome. Int J Obes Relat Metab Disord . 1995;19 Suppl 1:S52-9.

79. Duggirala R, Williams JT, Williams-Blangero S, Blangero J. A variance component approach to dichotomous trait linkage analysis using a threshold model. Genet Epidemiol . 1997;14:987-92.

80. Amos CI, Laing AE. A comparison of univariate and multivariate tests for genetic linkage. Genet Epidemiol . 1993;10:671-6.

81. Lamarche B, St-Pierre AC, Ruel IL, Cantin B, Dagenais GR, Despres JP. A prospective, population-based study of low density lipoprotein particle size as a risk factor for ischemic heart disease in men. Can J Cardiol . 2001;17:859-65.

82. Shen MM, Krauss RM, Lindgren FT, Forte TM. Heterogeneity of serum low density lipoproteins in normal human subjects. J Lipid Res . 1981;22:236-44.

83. Krauss RM, Burke DJ. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J Lipid Res . 1982;23:97-104.

84. Ghosh S, Basu MK, Schweppe JS. Charge heterogeneity of human low density lipoprotein (LDL). Proc Soc Exp Biol Med . 1973;142:1322-5.

85. Austin MA, Hokanson JE, Brunzell JD. Characterization of low-density lipoprotein subclasses: methodologic approaches and clinical relevance. Curr Opin Lipidol . 1994;5:395-403.

86. Gardner CD, Fortmann SP, Krauss RM. Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. Jama . 1996;276:875-81.

87. Stampfer MJ, Krauss RM, Ma J, Blanche PJ, Holl LG, Sacks FM, Hennekens CH. A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. Jama . 1996;276:882-8.

88. Chait A, Brazg RL, Tribble DL, Krauss RM. Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B. Am J Med . 1993;94:350-6.

89. de Graaf J, Hak-Lemmers HL, Hectors MP, Demacker PN, Hendriks JC, Stalenhoef AF. Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects. Arterioscler Thromb . 1991;11:298-306.

90. de Graaf J, Hendriks JC, Demacker PN, Stalenhoef AF. Identification of multiple dense LDL subfractions with enhanced susceptibility to in vitro oxidation among hypertriglyceridemic subjects. Normalization after clofibrate treatment. Arterioscler Thromb . 1993;13:712-9.

91. Dejager S, Bruckert E, Chapman MJ. Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia. J Lipid Res . 1993;34:295-308.

92. Tribble DL, Holl LG, Wood PD, Krauss RM. Variations in oxidative susceptibility among six low density lipoprotein subfractions of differing density and particle size. Atherosclerosis . 1992;93:189-99.

93. Campos H, Arnold KS, Balestra ME, Innerarity TL, Krauss RM. Differences in receptor binding of LDL subfractions. Arterioscler Thromb Vasc Biol . 1996;16:794-801.

94. Chen GC, Liu W, Duchateau P, Allaart J, Hamilton RL, Mendel CM, Lau K, Hardman DA, Frost PH, Malloy MJ, Kane JP. Conformational differences in human apolipoprotein B-100 among subspecies of low density lipoproteins (LDL). Association of altered proteolytic accessibility with decreased receptor binding of LDL subspecies from hypertriglyceridemic subjects. J Biol Chem . 1994;269:29121-8.

95. Galeano NF, Milne R, Marcel YL, Walsh MT, Levy E, Ngu'yen TD, Gleeson A, Arad Y, Witte L, Al-Haideri M, Rumsey SC, Deckelbaum RJ. Apoprotein B structure and receptor recognition of triglyceride-rich low density lipoprotein (LDL) is modified in small LDL but not in triglyceride-rich LDL of normal size. J Biol Chem . 1994;269:511-9.

96. Nigon F, Lesnik P, Rouis M, Chapman MJ. Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor. J Lipid Res . 1991;32:1741-53.

97. Teng B, Sniderman A, Krauss RM, Kwiterovich PO, Jr., Milne RW, Marcel YL. Modulation of apolipoprotein B antigenic determinants in human low density lipoprotein subclasses. J Biol Chem . 1985;260:5067-72.

98. Anber V, Griffin BA, McConnell M, Packard CJ, Shepherd J. Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans. Atherosclerosis . 1996;124:261-71.

99. Anber V, Millar JS, McConnell M, Shepherd J, Packard CJ. Interaction of very-low-density, intermediate-density, and low-density lipoproteins with human arterial wall proteoglycans. Arterioscler Thromb Vasc Biol . 1997;17:2507-14.

100. Camejo G, Rosengren B, Olson U, Lopez F, Olofson SO, Westerlund C, Bondjers G. Molecular basis of the association of arterial proteoglycans with low density lipoproteins: its effect on the structure of the lipoprotein particle. Eur Heart J . 1990;11 Suppl E:164-73.

101. Galeano NF, Al-Haideri M, Keyserman F, Rumsey SC, Deckelbaum RJ. Small dense low density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanism for increased atherogenicity. J Lipid Res . 1998;39:1263-73.

102. Bjornheden T, Babyi A, Bondjers G, Wiklund O. Accumulation of lipoprotein fractions and subfractions in the arterial wall, determined in an in vitro perfusion system. Atherosclerosis . 1996;123:43-56.

103. Nielsen LB. Transfer of low density lipoprotein into the arterial wall and risk of atherosclerosis. Atherosclerosis . 1996;123:1-15.

104. Vakkilainen J, Makimattila S, Seppala-Lindroos A, Vehkavaara S, Lahdenpera S, Groop PH, Taskinen MR, Yki-Jarvinen H. Endothelial dysfunction in men with small LDL particles. Circulation . 2000;102:716-21.

105. Veniant MM, Withycombe S, Young SG. Lipoprotein size and atherosclerosis susceptibility in Apoe(-/-) and Ldlr(-/-) mice. Arterioscler Thromb Vasc Biol . 2001;21:1567-70.

106. Miller BD, Alderman EL, Haskell WL, Fair JM, Krauss RM. Predominance of dense low-density lipoprotein particles predicts angiographic benefit of therapy in the Stanford Coronary Risk Intervention Project. Circulation . 1996;94:2146-53.

107. Zambon A, Hokanson JE, Brown BG, Brunzell JD. Evidence for a new pathophysiological mechanism for coronary artery disease regression: hepatic lipase-mediated changes in LDL density. Circulation . 1999;99:1959-64.

108. Campos H, Moye LA, Glasser SP, Stampfer MJ, Sacks FM. Low-density lipoprotein size, pravastatin treatment, and coronary events. Jama . 2001;286:1468-74.

109. Campos H, Roederer GO, Lussier-Cacan S, Davignon J, Krauss RM. Predominance of large LDL and reduced HDL2 cholesterol in normolipidemic men with coronary artery disease. Arterioscler Thromb Vasc Biol . 1995;15:1043-8.

110. Gray RS, Robbins DC, Wang W, Yeh JL, Fabsitz RR, Cowan LD, Welty TK, Lee ET, Krauss RM, Howard BV. Relation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians. The Strong Heart Study. Arterioscler Thromb Vasc Biol . 1997;17:2713-20.

111. Ruotolo G, Tettamanti C, Garancini MP, Ragogna F, Derosa G, Nardecchia L, Parlato F, Pozza G. Smaller, denser LDL particles are not a risk factor for cardiovascular disease in healthy nonagenarian women of the Cremona Population Study. Atherosclerosis . 1998;140:65-70.

112. Wahi S, Gatzka CD, Sherrard B, Simpson H, Collins V, Dowse G, Zimmet P, Jennings G, Dart AM. Risk factors for coronary heart disease in a population with a high prevalence of obesity and diabetes: a case-control study of the Polynesian population of Western Samoa. J Cardiovasc Risk . 1997;4:173-8.

113. Mykkanen L, Kuusisto J, Haffner SM, Laakso M, Austin MA. LDL size and risk of coronary heart disease in elderly men and women. Arterioscler Thromb Vasc Biol . 1999;19:2742-8.

114. Krauss RM. Is the size of low-density lipoprotein particles related to the risk of coronary heart disease? Jama . 2002;287:712-3.

115. Kwiterovich PO, Jr. Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity. Am J Cardiol . 2002;90:30i-47i.

116. Lindgren FT, Jensen LC, Wills RD, Freeman NK. Flotation rates, molecular weights and hydrated densities of the low-density lipoproteins. Lipids . 1969;4:337-44.

117. Austin MA, Breslow JL, Hennekens CH, Buring JE, Willett WC, Krauss RM. Low-density lipoprotein subclass patterns and risk of myocardial infarction. Jama . 1988;260:1917-21.

118. Tchernof A, Lamarche B, Prud'Homme D, Nadeau A, Moorjani S, Labrie F, Lupien PJ, Despres JP. The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care . 1996;19:629-37.

119. Campos H, Genest JJ, Blijlevens E, McNamara JR, Jenner JL, Ordovas JM, Wilson PW, Schaefer EJ. Low density lipoprotein particle size and coronary artery disease. Arterioscler Thromb . 1992;12:187-95.

120. Krauss RM, Blanche PJ. Detection and quantitation of LDL subfractions. Curr Opin Lipidol . 1992;3:377-83.

121. Otvos JD. Measurement of lipoprotein subclass profiles by nuclear magnetic resonance spectroscopy. Clin Lab . 2002;48:171-80.

122. Fisher WR, Hammond MG, Mengel MC, Warmke GL. A genetic determinant of the phenotypic variance of the molecular weight of low density lipoprotein. Proc Natl Acad Sci U S A . 1975;72:2347-51.

123. Haffner SM, D'Agostino R, Jr., Goff D, Howard B, Festa A, Saad MF, Mykkanen L. LDL size in African Americans, Hispanics, and non-Hispanic whites : the insulin resistance atherosclerosis study. Arterioscler Thromb Vasc Biol . 1999;19:2234-40.

124. Haffner SM, Mykkanen L, Valdez RA, Paidi M, Stern MP, Howard BV. LDL size and subclass pattern in a biethnic population. Arterioscler Thromb . 1993;13:1623-30.

125. Lamon-Fava S, Jimenez D, Christian JC, Fabsitz RR, Reed T, Carmelli D, Castelli WP, Ordovas JM, Wilson PW, Schaefer EJ. The NHLBI Twin Study: heritability of apolipoprotein A-I, B, and low density lipoprotein subclasses and concordance for lipoprotein(a). Atherosclerosis . 1991;91:97-106.

126. Christian JC, Kang KW, Norton JJ, Jr. Choice of an estimate of genetic variance from twin data. Am J Hum Genet . 1974;26:154-61.

127. Austin MA, Newman B, Selby JV, Edwards K, Mayer EJ, Krauss RM. Genetics of LDL subclass phenotypes in women twins. Concordance, heritability, and commingling analysis. Arterioscler Thromb . 1993;13:687-95.

128. Edwards KL, Mahaney MC, Motulsky AG, Austin MA. Pleiotropic genetic effects on LDL size, plasma triglyceride, and HDL cholesterol in families. Arterioscler Thromb Vasc Biol . 1999;19:2456-64.

129. Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR. Unique lipoprotein phenotype and genotype associated with exceptional longevity. Jama . 2003;290:2030-40.

130. Rainwater DL, Martin LJ, Comuzzie AG. Genetic control of coordinated changes in HDL and LDL size phenotypes. Arterioscler Thromb Vasc Biol . 2001;21:1829-33.

131. Austin MA, Edwards KL, Monks SA, Koprowicz KM, Brunzell JD, Motulsky AG, Mahaney MC, Hixson JE. Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemia. J Lipid Res . 2003;44:2161-8.

132. Krauss RM. Dietary and genetic effects on low-density lipoprotein heterogeneity. Annu Rev Nutr . 2001;21:283-95.

133. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, Bales CW, Henes S, Samsa GP, Otvos JD, Kulkarni KR, Slentz CA. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med . 2002;347:1483-92.

134. Terry RB, Wood PD, Haskell WL, Stefanick ML, Krauss RM. Regional adiposity patterns in relation to lipids, lipoprotein cholesterol, and lipoprotein subfraction mass in men. J Clin Endocrinol Metab . 1989;68:191-9.

135. Reaven GM, Chen YD, Jeppesen J, Maheux P, Krauss RM. Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest . 1993;92:141-6.

136. Austin MA. Genetic and environmental influences on LDL subclass phenotypes. Clin Genet . 1994;46:64-70.

137. Maclean CJ, Morton NE, Elston RC, Yee S. Skewness in commingled distributions. Biometrics . 1976;32:695-9.

138. Austin MA, Jarvik GP, Hokanson JE, Edwards K. Complex segregation analysis of LDL peak particle diameter. Genet Epidemiol . 1993;10:599-604.

139. Friedlander Y, Kark JD, Sinnreich R, Edwards KL, Austin MA. Inheritance of LDL peak particle diameter: results from a segregation analysis in Israeli families. Genet Epidemiol . 1999;16:382-96.

140. Austin MA, Krauss RM. Genetic control of low-density-lipoprotein subclasses. Lancet . 1986;2:592-5.

141. Austin MA, King MC, Vranizan KM, Newman B, Krauss RM. Inheritance of low-density lipoprotein subclass patterns: results of complex segregation analysis. Am J Hum Genet . 1988;43:838-46.

142. Austin MA, Brunzell JD, Fitch WL, Krauss RM. Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis . 1990;10:520-30.

143. Vakkilainen J, Pajukanta P, Cantor RM, Nuotio IO, Lahdenpera S, Ylitalo K, Pihlajamaki J, Kovanen PT, Laakso M, Viikari JS, Peltonen L, Taskinen MR. Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia. Eur J Hum Genet . 2002;10:547-52.

144. de Graaf J, Swinkels DW, de Haan AF, Demacker PN, Stalenhoef AF. Both inherited susceptibility and environmental exposure determine the low-density lipoprotein-subfraction pattern distribution in healthy Dutch families. Am J Hum Genet . 1992;51:1295-310.

145. Bredie SJ, Kiemeney LA, de Haan AF, Demacker PN, Stalenhoef AF. Inherited susceptibility determines the distribution of dense low- density lipoprotein subfraction profiles in familial combined hyperlipidemia. Am J Hum Genet . 1996;58:812-22.

146. Austin MA, Talmud PJ, Luong LA, Haddad L, Day IN, Newman B, Edwards KL, Krauss RM, Humphries SE. Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib- pair linkage analysis of DZ women twins. Am J Hum Genet . 1998;62:406-19.

147. Rainwater DL, Almasy L, Blangero J, Cole SA, VandeBerg JL, MacCluer JW, Hixson JE. A genome search identifies major quantitative trait loci on human chromosomes 3 and 4 that influence cholesterol concentrations in small LDL particles. Arterioscler Thromb Vasc Biol . 1999;19:777-83.

148. Rotter JI, Bu X, Cantor RM, Warden CH, Brown J, Gray RJ, Blanche PJ, Krauss RM, Lusis AJ. Multilocus genetic determinants of LDL particle size in coronary artery disease families. Am J Hum Genet . 1996;58:585-94.

149. Allayee H, Aouizerat BE, Cantor RM, Dallinga-Thie GM, Krauss RM, Lanning CD, Rotter JI, Lusis AJ, de Bruin TW. Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype. Am J Hum Genet . 1998;63:577-85.

150. Hokanson JE, Brunzell JD, Jarvik GP, Wijsman EM, Austin MA. Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. Am J Hum Genet . 1999;64:608-18.

151. Allayee H, Dominguez KM, Aouizerat BE, Krauss RM, Rotter JI, Lu J, Cantor RM, de Bruin TW, Lusis AJ. Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia. J Lipid Res . 2000;41:245-52.

152. Talmud PJ, Edwards KL, Turner CM, Newman B, Palmen JM, Humphries SE, Austin MA. Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter. Circulation . 2000;101:2461-6.

153. Nishina PM, Johnson JP, Naggert JK, Krauss RM. Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19. Proc Natl Acad Sci U S A . 1992;89:708-12.

154. Austin MA, Wijsman E, Guo SW, Krauss RM, Brunzell JD, Deeb S. Lack of evidence for linkage between low-density lipoprotein subclass phenotypes and the apolipoprotein B locus in familial combined hyperlipidemia. Genet Epidemiol . 1991;8:287-97.

155. LaBelle M, Austin MA, Rubin E, Krauss RM. Linkage analysis of low-density lipoprotein subclass phenotypes and the apolipoprotein B gene. Genet Epidemiol . 1991;8:269-75.

156. Austin MA, Stephens K, Walden CE, Wijsman E. Linkage analysis of candidate genes and the small, dense low-density lipoprotein phenotype. Atherosclerosis . 1999;142:79-87.

157. Naggert JK, Recinos A, Lamerdin JE, Krauss RM, Nishina PM. The atherogenic lipoprotein phenotype is not caused by a mutation in the coding region of the low density lipoprotein receptor gene. Clin Genet . 1997;51:236-40.

158. Schaefer EJ, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM, Castelli WP, Wilson PW. Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. Arterioscler Thromb . 1994;14:1105-13.

159. Okumura K, Matsui H, Kawakami K, Numaguchi Y, Kaneko S, Morishima I, Mokuno S, Toki Y, Hayakawa T. Relationship between the apolipoprotein E and angiotensin-converting enzyme genotypes and LDL particle size in Japanese subjects. Clin Chim Acta . 1999;285:91-103.

160. Skoglund-Andersson C, Ehrenborg E, Fisher RM, Olivecrona G, Hamsten A, Karpe F. Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men. Atherosclerosis . 2003;167:311-7.

161. Haffner SM, Stern MP, Miettinen H, Robbins D, Howard BV. Apolipoprotein E polymorphism and LDL size in a biethnic population. Arterioscler Thromb Vasc Biol . 1996;16:1184-8.

162. Nikkila M, Pitkajarvi T, Koivula T, Solakivi T, Lehtimaki T, Laippala P, Jokela H, Lehtomaki E, Seppa K, Sillanaukee P. Women have a larger and less atherogenic low density lipoprotein particle size than men. Atherosclerosis . 1996;119:181-90.

163. Zhao SP, Verhoeven MH, Vink J, Hollaar L, van der Laarse A, de Knijff P, van 't Hooft FM. Relationship between apolipoprotein E and low density lipoprotein particle size. Atherosclerosis . 1993;102:147-54.

164. Isasi CR, Shea S, Deckelbaum RJ, Couch SC, Starc TJ, Otvos JD, Berglund L. Apolipoprotein epsilon2 allele is associated with an anti-atherogenic lipoprotein profile in children: The Columbia University BioMarkers Study. Pediatrics . 2000;106:568-75.

165. Barbagallo CM, Polizzi F, Severino M, Rizzo M, Vivona N, Onorato F, Caldarella R, Cefalu AB, Noto D, Notarbartolo A, Averna MR. ApoE polymorphism in a small Mediterranean island: relationships with plasma lipids, lipoproteins and LDL particle size. Eur J Epidemiol . 2001;17:707-13.

166. Dart AM, Cooper B. Independent effects of Apo E phenotype and plasma triglyceride on lipoprotein particle sizes in the fasting and postprandial states. Arterioscler Thromb Vasc Biol . 1999;19:2465-73.

167. Vohl MC, Tchernof A, Dionne FT, Moorjani S, Prud'homme D, Bouchard C, Nadeau A, Lupien PJ, Despres JP. The apoB-100 gene EcoRI polymorphism influences the relationship between features of the insulin resistance syndrome and the hyper-apoB and dense LDL phenotype in men. Diabetes . 1996;45:1405-11.

168. Vedie B, Jeunemaitre X, Megnien JL, Myara I, Trebeden H, Simon A, Moatti N. Charge heterogeneity of LDL in asymptomatic hypercholesterolemic men is related to lipid parameters and variations in the ApoB and CIII genes. Arterioscler Thromb Vasc Biol . 1998;18:1780-9.

169. Couture P, Otvos JD, Cupples LA, Wilson PW, Schaefer EJ, Ordovas JM. Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study. Atherosclerosis . 2000;148:337-43.

170. St-Pierre J, Lemieux I, Miller-Felix I, Prud'homme D, Bergeron J, Gaudet D, Nadeau A, Despres JP, Vohl MC. Visceral obesity and hyperinsulinemia modulate the impact of the microsomal triglyceride transfer protein -493G/T polymorphism on plasma lipoprotein levels in men. Atherosclerosis . 2002;160:317-24.

171. Chen L, Yoshino G, Maeda E, Zeng S. Effect of microsomal triglyceride transfer protein gene polymorphism in the promoter region on dyslipidemia in type 2 diabetic subjects. Chin Med J (Engl) . 2003;116:215-7.

172. Okumura K, Matsui H, Ogawa Y, Takahashi R, Matsubara K, Imai H, Imamura A, Mizuno T, Tsuzuki M, Kitamura Y. The polymorphism of the beta3-adrenergic receptor gene is associated with reduced low-density lipoprotein particle size. Metabolism . 2003;52:356-61.

173. Miesenbock G, Holzl B, Foger B, Brandstatter E, Paulweber B, Sandhofer F, Patsch JR. Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities. J Clin Invest . 1993;91:448-55.

174. Bertolini S, Simone ML, Pes GM, Ghisellini M, Rolleri M, Bellocchio A, Elicio N, Masturzo P, Calandra S. Pseudodominance of lipoprotein lipase (LPL) deficiency due to a nonsense mutation (Tyr302>Term) in exon 6 of LPL gene in an Italian family from Sardinia (LPL(Olbia)). Clin Genet . 2000;57:140-7.

175. Sawano M, Watanabe Y, Ohmura H, Shimada K, Daida H, Mokuno H, Yamaguchi H. Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile. Jpn Circ J . 2001;65:310-4.

176. Humphries SE, Berglund L, Isasi CR, Otvos JD, Kaluski D, Deckelbaum RJ, Shea S, Talmud PJ. Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and sub-population distribution in Hispanic and non-Hispanic white subjects: the Columbia University BioMarkers Study. Nutr Metab Cardiovasc Dis . 2002;12:163-72.

177. Ruel IL, Gaudet D, Perron P, Bergeron J, Julien P, Lamarche B. Characterization of LDL particle size among carriers of a defective or a null mutation in the lipoprotein lipase gene: the Quebec LIPD Study. Arterioscler Thromb Vasc Biol . 2002;22:1181-6.

178. Couture P, Otvos JD, Cupples LA, Wilson PW, Schaefer EJ, Ordovas JM. Association of the A-204C polymorphism in the cholesterol 7alpha- hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. J Lipid Res . 1999;40:1883-9.

179. Schaefer EJ, Brousseau ME, Diffenderfer MR, Cohn JS, Welty FK, O'Connor J, Jr., Dolnikowski GG, Wang J, Hegele RA, Jones PJ. Cholesterol and apolipoprotein B metabolism in Tangier disease. Atherosclerosis . 2001;159:231-6.

180. Kuivenhoven JA, Hovingh GK, van Tol A, Jauhiainen M, Ehnholm C, Fruchart JC, Brinton EA, Otvos JD, Smelt AH, Brownlee A, Zwinderman AH, Hayden MR, Kastelein JJ. Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size. Atherosclerosis . 2003;171:311-9.

181. Austin MA, Talmud PJ, Farin FM, Nickerson DA, Edwards KL, Leonetti D, McNeely MJ, Viernes HM, Humphries SE, Fujimoto WY. Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans. Biochim Biophys Acta . 2004;1688:1-9.

182. Russo GT, Meigs JB, Cupples LA, Demissie S, Otvos JD, Wilson PW, Lahoz C, Cucinotta D, Couture P, Mallory T, Schaefer EJ, Ordovas JM. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study. Atherosclerosis . 2001;158:173-81.

183. Brown S, Ordovas JM, Campos H. Interaction between the APOC3 gene promoter polymorphisms, saturated fat intake and plasma lipoproteins. Atherosclerosis . 2003;170:307-13.

184. Osgood D, Corella D, Demissie S, Cupples LA, Wilson PW, Meigs JB, Schaefer EJ, Coltell O, Ordovas JM. Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study. J Clin Endocrinol Metab . 2003;88:2869-79.

185. Zambon A, Deeb SS, Hokanson JE, Brown BG, Brunzell JD. Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler Thromb Vasc Biol . 1998;18:1723-9.

186. Carr MC, Ayyobi AF, Murdoch SJ, Deeb SS, Brunzell JD. Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women. Arterioscler Thromb Vasc Biol . 2002;22:667-73.

187. Couture P, Otvos JD, Cupples LA, Lahoz C, Wilson PW, Schaefer EJ, Ordovas JM. Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study. Arterioscler Thromb Vasc Biol . 2000;20:815-22.

188. Sakai N, Matsuzawa Y, Hirano K, Yamashita S, Nozaki S, Ueyama Y, Kubo M, Tarui S. Detection of two species of low density lipoprotein particles in cholesteryl ester transfer protein deficiency. Arterioscler Thromb . 1991;11:71-9.

189. Ordovas JM, Cupples LA, Corella D, Otvos JD, Osgood D, Martinez A, Lahoz C, Coltell O, Wilson PW, Schaefer EJ. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler Thromb Vasc Biol . 2000;20:1323-9.

190. Brousseau ME, O'Connor JJ, Jr., Ordovas JM, Collins D, Otvos JD, Massov T, McNamara JR, Rubins HB, Robins SJ, Schaefer EJ. Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency: Veterans Affairs HDL Cholesterol Intervention Trial. Arterioscler Thromb Vasc Biol . 2002;22:1148-54.

191. Bernard S, Moulin P, Lagrost L, Picard S, Elchebly M, Ponsin G, Chapuis F, Berthezene F. Association between plasma HDL-cholesterol concentration and Taq1B CETP gene polymorphism in non-insulin-dependent diabetes mellitus. J Lipid Res . 1998;39:59-65.

192. Okumura K, Matsui H, Kamiya H, Saburi Y, Hayashi K, Hayakawa T. Differential effect of two common polymorphisms in the cholesteryl ester transfer protein gene on low-density lipoprotein particle size. Atherosclerosis . 2002;161:425-31.

193. Wang J, Qiang H, Chen D, Zhang C, Zhuang Y. CETP gene mutation (D442G) increases low-density lipoprotein particle size in patients with coronary heart disease. Clin Chim Acta . 2002;322:85-90.

194. Hayaishi-Okano R, Yamasaki Y, Ohtoshi K, Yasuda T, Katakami N, Hirano T, Yoshino G, Kajimoto Y, Hori M. NAD (P) H oxidase p22 phox C242T polymorphism affects LDL particle size and insulin resistance in Japanese subjects. J Atheroscler Thromb . 2002;9:200-5.

195. Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomer K, Schenck-Gustafsson K, Hamsten A, Fisher RM. A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. Atherosclerosis . 2003;167:265-73.

196. Vega GL, Clark LT, Tang A, Marcovina S, Grundy SM, Cohen JC. Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). J Lipid Res . 1998;39:228-32.

197. Kozaki K, Gotoda T, Kawamura M, Shimano H, Yazaki Y, Ouchi Y, Orimo H, Yamada N. Mutational analysis of human lipoprotein lipase by carboxy-terminal truncation. J Lipid Res . 1993;34:1765-72.

198. Patsch W, Ostlund R, Kuisk I, Levy R, Schonfeld G. Characterization of lipoprotein in a kindred with familial hypercholesterolemia. J Lipid Res . 1982;23:1196-205.

199. Slack J, Mills GL. Anomalous low density lipoproteins in familial hyperbetalipoproteinaemia. Clin Chim Acta . 1970;29:15-25.

200. Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation . 1990;82:495-506.

201. Edwards KL, Austin MA, Newman B, Mayer E, Krauss RM, Selby JV. Multivariate analysis of the insulin resistance syndrome in women. Arterioscler Thromb . 1994;14:1940-5.

202. Edwards KL, Newman B, Mayer E, Selby JV, Krauss RM, Austin MA. Heritability of factors of the insulin resistance syndrome in women twins. Genet Epidemiol . 1997;14:241-53.

203. Edwards KL, Talmud PJ, Newman B, Krauss RM, Austin MA. Lipoprotein candidate genes for multivariate factors of the insulin resistance syndrome: a sib-pair linkage analysis in women twins. Twin Res . 2001;4:41-7.

204. Juo SH, Bredie SJ, Kiemeney LA, Demacker PN, Stalenhoef AF. A common genetic mechanism determines plasma apolipoprotein B levels and dense LDL subfraction distribution in familial combined hyperlipidemia. Am J Hum Genet . 1998;63:586-94.

205. Jarvik GP, Brunzell JD, Austin MA, Krauss RM, Motulsky AG, Wijsman E. Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype. Arterioscler Thromb . 1994;14:1687-94.

206. Austin MA, Horowitz H, Wijsman E, Krauss RM, Brunzell J. Bimodality of plasma apolipoprotein B levels in familial combined hyperlipidemia. Atherosclerosis . 1992;92:67-77.

207. Jiao S, Cole TG, Kitchens RT, Pfleger B, Schonfeld G. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res . 1990;31:467-77.

208. Singh AT, Rainwater DL, Kammerer CM, Sharp RM, Poushesh M, Shelledy WR, VandeBerg JL. Dietary and genetic effects on LDL size measures in baboons. Arterioscler Thromb Vasc Biol . 1996;16:1448-53.

209. Rainwater DL, Kammerer CM, Mahaney MC, Rogers J, Cox LA, Schneider JL, VandeBerg JL. Localization of genes that control LDL size fractions in baboons. Atherosclerosis . 2003;168:15-22.

210. Wu L, Hunt S, Afman G, Nichols H, Adams T, Lalouel J, Williams R. Genetic concordance of and exercise effects on low density lipoprotein subfractions in Utah Twins. Circulation . 1988;78:II-481.

211. Dreon DM, Fernstrom HA, Williams PT, Krauss RM. Reduced LDL particle size in children consuming a very-low-fat diet is related to parental LDL-subclass patterns. Am J Clin Nutr . 2000;71:1611-6.

212. Zambon A, Deeb SS, Brown BG, Hokanson JE, Brunzell JD. Common hepatic lipase gene promoter variant determines clinical response to intensive lipid-lowering treatment. Circulation . 2001;103:792-8.

213. Trevisan M, Liu J, Bahsas FB, Menotti A. Syndrome X and mortality: a population-based study. Risk Factor and Life Expectancy Research Group. Am J Epidemiol . 1998;148:958-66.

214. Schoonjans K, Martin G, Staels B, Auwerx J. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr Opin Lipidol . 1997;8:159-66.

215. Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation . 1998;98:2088-93.

216. Flavell DM, Pineda Torra I, Jamshidi Y, Evans D, Diamond JR, Elkeles RS, Bujac SR, Miller G, Talmud PJ, Staels B, Humphries SE. Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects. Diabetologia . 2000;43:673-80.

217. Sapone A, Peters JM, Sakai S, Tomita S, Papiha SS, Dai R, Friedman FK, Gonzalez FJ. The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants. Pharmacogenetics . 2000;10:321-33.

218. Costet P, Legendre C, More J, Edgar A, Galtier P, Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J Biol Chem . 1998;273:29577-85.

219. Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem . 2000;275:16638-42.

220. Mancini FP, Lanni A, Sabatino L, Moreno M, Giannino A, Contaldo F, Colantuoni V, Goglia F. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. FEBS Lett . 2001;491:154-8.

221. Lee JH, Reed DR, Li WD, Xu W, Joo EJ, Kilker RL, Nanthakumar E, North M, Sakul H, Bell C, Price RA. Genome scan for human obesity and linkage to markers in 20q13. Am J Hum Genet . 1999;64:196-209.

222. Lembertas AV, Perusse L, Chagnon YC, Fisler JS, Warden CH, Purcell-Huynh DA, Dionne FT, Gagnon J, Nadeau A, Lusis AJ, Bouchard C. Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J Clin Invest . 1997;100:1240-7.

223. Norman RA, Tataranni PA, Pratley R, Thompson DB, Hanson RL, Prochazka M, Baier L, Ehm MG, Sakul H, Foroud T, Garvey WT, Burns D, Knowler WC, Bennett PH, Bogardus C, Ravussin E. Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians. Am J Hum Genet . 1998;62:659-68.

224. Jiang XC, Qin S, Qiao C, Kawano K, Lin M, Skold A, Xiao X, Tall AR. Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med . 2001;7:847-52.

225. Oram JF, Wolfbauer G, Vaughan AM, Tang C, Albers JJ. Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells. J Biol Chem . 2003;278:52379-85.

226. Bosse Y, Vohl MC, Despres JP, Lamarche B, Rice T, Rao DC, Bouchard C, Perusse L. Heritability of LDL peak particle diameter in the Quebec Family Study. Genet Epidemiol . 2003;25:375-81.

227. Bosse Y, Perusse L, Despres JP, Lamarche B, Chagnon YC, Rice T, Rao DC, Bouchard C, Vohl MC. Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter. Circulation . 2003;107:2361-8.